PRINCIPAL
INVESTIGATORS
Principal Investigator
Viviana Moschese
Background
My medical and scientific career in Rome, where I studied Medicine and specialized in Pediatrics and in Allergy and Immunology. During this time, I developed a strong interest in Immunology, allergy and infectious diseases. My experiences at renowned centers in France and United States together with The Karolinska Institute in Sweden allowed me to deepen my expertise in immunology and virology, contributing to studies on HIV pathogenesis and a better understanding of immunological mechanisms of defense.
Thus, my work expanded to translational immunology, particularly to the characterization of primary immunodeficiencies. My scientific efforts spanned from molecular and functional investigation on primary antibody defects to the interplay between immune response and immune dysregulation. In this role, I have successfully integrated clinical care with research aimed at a better understanding of immune-mediated and rare disorders on the field. My research has increasingly focused on translational immunology regarding primary immunodeficiencies, atopic disorders, and antibody defects using advanced molecular and genetic techniques to improve diagnostic precision and individualized therapeutic strategies.
Research
Our research group is dedicated to understanding the mechanisms of immune dysregulation that contribute to allergic and immunological diseases. We employ a strong translational approach that connects clinical observations with laboratory research.
Our focus includes recurrent infections, atopic disorders, and primary immunodeficiencies, particularly those related to antibody defects integrating advanced genetic, molecular, and immunological analyses. This integrated approach has led to the discovery of novel disease-causing genes and variants of known genes associated with atypical phenotypes. It has also enhanced our understanding of the pathogenic pathways driving immune dysfunction. Our goal is to identify biomarkers for disease progression and therapeutic response, thereby enabling precision diagnosis and personalized treatments. Additionally, our group actively participates in national and international collaborative studies aimed at improving the clinical management and long-term outcomes of patients with rare immune-mediated disorders.
Publications
Giardino G, Di Matteo G, Giliani S, Ferrari S, Lougaris V, Badolato R, Conti F, Romano R, Cicalese MP, Ricci S, Barzaghi F, Marzollo A, Cifaldi C, Montin D, Lodi L, Cirillo E, Martire B, Trizzino A, Sgrulletti M, Moschese V, Comegna M, Castaldo G, Tommasini A, Azzari C, Cancrini C, Aiuti A, Pignata C. (2025) Consensus of the Italian Primary Immunodeficiency Network on the use and interpretation of genetic testing for diagnosing inborn errors of immunity. J Allergy Clin Immunol. Apr;155(4):1149-1160. doi: 10.1016/j.jaci.2024.11.030. Epub 2024 Nov 30.PMID: 39622296
Sgrulletti M, Baselli LA, Castagnoli R, Del Duca E, Graziani S, Moscato GMF, Di Cesare S, Di Matteo G, Cifaldi C, Rossano M, Ballerini C, Piciocchi A, Licari A, Marseglia GL, Consolini R, Moschese V. (2024) IPINeT Ped-unPAD Study: Goals, Design, and Preliminary Results. J Clin Med. Jul 24;13(15):4321. doi: 10.3390/jcm13154321.PMID: 39124588
Ottaviano G, Marinoni M, Graziani S, Sibson K, Barzaghi F, Bertolini P, Chini L, Corti P, Cancrini C, D'Alba I, Gabelli M, Gallo V, Giancotta C, Giordano P, Lassandro G, Martire B, Angarano R, Mastrodicasa E, Bava C, Miano M, Naviglio S, Verzegnassi F, Saracco P, Trizzino A, Biondi A, Pignata C, Moschese V. (2020) Rituximab Unveils Hypogammaglobulinemia and Immunodeficiency in Children with Autoimmune Cytopenia. J Allergy Clin Immunol Pract Jan;8(1):273-282.
Israni M, Nicholson B, Mahlaoui N, Obici L, Rossi-Semerano L, Lachmann H, Hayward G, Avramovič MZ, Guffroy A, Dalm V, Rimmer R, Solis L, Villar C, Gennery AR, Skeffington S, Nordin J, Warnatz K, Korganow AS, Antón J, Cattalini M, Amin T, Berg S, Soler-Palacin P, Burns SO, Campbell M; (2022) RITA-ERN Transition Working Group Consortium. Current Transition Practice for Primary Immunodeficiencies and Autoinflammatory Diseases in Europe: a RITA-ERN Survey. J Clin Immunol. 2023 Jan;43(1):206-216.
Patruno C, Fabbrocini G, Lauletta G, Boccaletti V, Colonna C, Cavalli R, Neri I, Ortoncelli M, Schena D, Stingeni L, Hansel K, Piccolo V, Di Brizzi V, Potenza C, Tolino E, Bianchi L, Manti S, De Pasquale R, Di Lernia V, Caminiti L, Galli E, Coppo P, Chiricozzi A, De Simone C, Guerriero C, Amoruso FG, Provenzano E, Leonardi S, Licari A, Marseglia GL, Palermo A, Di Pillo S, Russo D, Moschese V, Patella V, Peduto T, Ferreli C, Zangari P, Veronese F, Berti SF, Gruber M, Pezzolo E, Termine S, Satta R, Dragoni F, Esposito M, Fargnoli MC, Chiodini P, Vallone Y, di Vico F, Picone V, Napolitano M. (2023) A 52-week multicenter retrospective real-world study on effectiveness and safety of dupilumab in children with atopic dermatitis aged from 6 to 11 years. J Dermatolog Treat. Dec;34(1):2246602.